We investigated how inositol supplementation could counteract heart issues caused by lithium in mice. Our study involved four groups of mice to explore the varying effects of inositol. One group received lithium alone, another received lithium followed by inositol, a third group had both lithium and inositol from the start, and a control group had no treatment at all.
The results were promising. We found that inositol had a protective effect against the heart damage typically associated with lithium. Specifically, it helped improve heart function and reduced susceptibility to arrhythmias—irregular heartbeats. We also noted that inositol seemed to restore healthy levels of certain proteins crucial for heart health, helping to reduce cell enlargement and stress associated with hypertrophy.
Interestingly, the benefits of inositol were evident regardless of whether it was given alongside lithium or afterward as a treatment. These findings suggest that inositol could be a valuable addition to therapy for those facing lithium-induced cardiac issues, offering a potential pathway to better heart health.
Read More
8
ITPP improves heart function in PH
Myo-inositol trispyrophosphate prevents right ventricular failure and improves survival in monocrotaline-induced pulmonary hypertension in the rat.
We investigated the effects of myo-inositol trispyrophosphate (ITPP) on rats with pulmonary hypertension (PH), a condition that often leads to serious heart issues. To do this, we injected some rats with monocrotaline to induce PH and treated others with a placebo. For five weeks, we closely monitored their heart function using echocardiograms and other advanced techniques.
Our findings revealed that ITPP significantly reduced mortality linked to PH. While it didn't change the increasing resistance in the pulmonary vessels, ITPP importantly alleviated hypoxia within the right ventricle (RV), which is crucial for maintaining heart function. This reduction in RV hypoxia not only improved heart performance but also decreased stress on the heart’s structure.
Furthermore, we noticed that ITPP appeared to inhibit an increase in a specific protein associated with low oxygen levels, though it didn't affect the density of blood vessels in the RV. Overall, this suggests that enhancing oxygen delivery with ITPP could provide a crucial therapeutic avenue for improving heart health in patients suffering from pulmonary hypertension.
Read More
Most Useful Reviews
7.5
Support cardiovascular health
9 people found this helpful
L-Theanine, an amino acid from green tea, promotes relaxation without drowsiness and supports the cardiovascular system. I've found it particularly effective when taken after a meal. Its effects are gradual, offering a soft sense of balance and clarity of thought without addiction or side effects. I've noticed no negative effects and consider it a noteworthy supplement that delivers on its promises.
Read More
9
Enhanced mood stability
4 people found this helpful
I’ve recommended L-Theanine for my brother as per his doctor’s advice for stress and memory issues. After a month of use, he’s noticeably happier, more judicious, and his condition has significantly improved. I believe L-Theanine is one of the best remedies. If you find this helpful, please give it a like.
Read More
7.5
Improved stress response
4 people found this helpful
If you're stressed and fatigued, this product is for you. After taking it for a month, I've noticed a significant change: I'm calmer at work, my family relationships have improved, and I've overcome apathy. L-Theanine also reduces risks for diabetes and cardiovascular disease. If this resonates with you, I suggest trying these pills for a positive change.
We investigated how inositol supplementation could counteract heart issues caused by lithium in mice. Our study involved four groups of mice to explore the varying effects of inositol. One group received lithium alone, another received lithium followed by inositol, a third group had both lithium and inositol from the start, and a control group had no treatment at all.
The results were promising. We found that inositol had a protective effect against the heart damage typically associated with lithium. Specifically, it helped improve heart function and reduced susceptibility to arrhythmias—irregular heartbeats. We also noted that inositol seemed to restore healthy levels of certain proteins crucial for heart health, helping to reduce cell enlargement and stress associated with hypertrophy.
Interestingly, the benefits of inositol were evident regardless of whether it was given alongside lithium or afterward as a treatment. These findings suggest that inositol could be a valuable addition to therapy for those facing lithium-induced cardiac issues, offering a potential pathway to better heart health.
Read More
8
ITPP improves heart function in PH
Myo-inositol trispyrophosphate prevents right ventricular failure and improves survival in monocrotaline-induced pulmonary hypertension in the rat.
We investigated the effects of myo-inositol trispyrophosphate (ITPP) on rats with pulmonary hypertension (PH), a condition that often leads to serious heart issues. To do this, we injected some rats with monocrotaline to induce PH and treated others with a placebo. For five weeks, we closely monitored their heart function using echocardiograms and other advanced techniques.
Our findings revealed that ITPP significantly reduced mortality linked to PH. While it didn't change the increasing resistance in the pulmonary vessels, ITPP importantly alleviated hypoxia within the right ventricle (RV), which is crucial for maintaining heart function. This reduction in RV hypoxia not only improved heart performance but also decreased stress on the heart’s structure.
Furthermore, we noticed that ITPP appeared to inhibit an increase in a specific protein associated with low oxygen levels, though it didn't affect the density of blood vessels in the RV. Overall, this suggests that enhancing oxygen delivery with ITPP could provide a crucial therapeutic avenue for improving heart health in patients suffering from pulmonary hypertension.
Read More
User Reviews
USERS' SCORE
Good
Based on 9 Reviews
8.1
All Reviews
Positive Reviews
Negative Reviews
7.5
Support cardiovascular health
9 people found this helpful
L-Theanine, an amino acid from green tea, promotes relaxation without drowsiness and supports the cardiovascular system. I've found it particularly effective when taken after a meal. Its effects are gradual, offering a soft sense of balance and clarity of thought without addiction or side effects. I've noticed no negative effects and consider it a noteworthy supplement that delivers on its promises.
Read More
9
Enhanced mood stability
4 people found this helpful
I’ve recommended L-Theanine for my brother as per his doctor’s advice for stress and memory issues. After a month of use, he’s noticeably happier, more judicious, and his condition has significantly improved. I believe L-Theanine is one of the best remedies. If you find this helpful, please give it a like.
Read More
7.5
Improved stress response
4 people found this helpful
If you're stressed and fatigued, this product is for you. After taking it for a month, I've noticed a significant change: I'm calmer at work, my family relationships have improved, and I've overcome apathy. L-Theanine also reduces risks for diabetes and cardiovascular disease. If this resonates with you, I suggest trying these pills for a positive change.
Read More
7.5
Supports mental performance
4 people found this helpful
L-Theanine is an amino acid that enhances focus and relaxes muscles without sedative effects. It's better than caffeine stimulants and benefits cardiovascular health by reducing risks of heart disease and blood pressure. Combining it with caffeine maximises brain function, and I highly recommend trying it.
Read More
6
Calms nerves effectively
6 people found this helpful
I really appreciate this supplement and have ordered it twice. Over the months, I've seen a noticeable boost in my concentration and a calmer response to stress. It doesn't induce sleepiness and has many benefits, including support for cardiovascular function and normalising blood pressure. The capsules are comfortable, and I highly recommend it to students and athletes.
Cardiovascular disease (CVD) is a broad term that encompasses a range of heart and blood vessel disorders. This can include conditions such as coronary artery disease, which leads to heart attacks; cerebrovascular disease that results in strokes; and peripheral artery disease affecting blood flow to the limbs. The key risk factors for CVD often include high blood pressure, high cholesterol, obesity, smoking, a sedentary lifestyle, and diabetes. By identifying and managing these risk factors, individuals can significantly reduce their likelihood of developing cardiovascular problems.
Prevention and treatment strategies often involve lifestyle modifications such as adopting a heart-healthy diet rich in fruits, vegetables, whole grains, and lean proteins, alongside engaging in regular physical activity. In some cases, medications might be necessary to control blood pressure or cholesterol levels. Regular check-ups with a healthcare provider are essential for monitoring heart health, especially for individuals with a family history of CVD. Understanding the signs and symptoms of cardiovascular issues—like chest pain, shortness of breath, or fatigue—can help in seeking timely medical attention, ultimately leading to better outcomes.
L-theanine is a naturally occurring amino acid most commonly found in tea leaves, particularly green tea, and is known for its potential calming effects. While caffeine can lead to increased alertness and focus, L-theanine promotes relaxation without causing drowsiness, making it a popular supplement among those seeking to enhance their mental performance while also managing stress. It is believed to work by influencing the production of neurotransmitters, such as serotonin and dopamine, which can positively affect mood and cognitive function.
Many users report that L-theanine may enhance the benefits of caffeine, leading to improved focus and reduced feelings of jitteriness when consumed together. This unique combination is often sought after by students and professionals during periods of intense concentration or study. As a dietary supplement, L-theanine is available in various forms, including capsules, powders, and tea, allowing individuals to choose the method that best fits their lifestyle. Typically, dosages range from 100 to 400 mg per day, depending on the intended effects and individual tolerance.
Based on user reviews, the timeline for seeing results from supplements like L-Theanine can vary. Many users report noticeable improvements in their mood and relaxation levels after about a month of consistent use. For instance, one user mentioned their brother significantly improved in mood and cognitive abilities after a month of using L-Theanine as advised by his doctor Read Review. Another reviewer shared their experience of feeling calmer and emotionally balanced after a month, attributing the positive changes to the supplement's effects Read Review.
Additionally, several users have noted improvements in cardiovascular health metrics, such as normalizing blood pressure and reducing risks associated with heart disease, albeit without a specific timeline provided. The general consensus amongst users suggests that with regular intake, benefits can manifest within weeks to a month, making it a valuable addition to a health regimen for those managing cardiovascular concerns Read ReviewRead Review.
Based on the available research data, there is some scientific support for specific forms of inositol supplements in relation to cardiovascular health. One study [1] focused on inositol's protective effects against heart damage induced by lithium in mice. The results indicated that inositol supplementation helped improve heart function and reduced the risk of irregular heartbeats, suggesting it might offer therapeutic benefits for those dealing with heart health issues, particularly associated with lithium.
Additionally, research on myo-inositol trispyrophosphate (ITPP) demonstrates positive outcomes in rats suffering from pulmonary hypertension [2]. The study found that ITPP improved heart function and reduced hypoxia in the right ventricle, indicating its potential to alleviate stress on the heart under certain conditions. Overall, while these findings are promising, they primarily derive from animal studies, and further research in human populations would be needed to fully validate the cardiovascular benefits of inositol and its derivatives.
Based on user reviews, many individuals have reported significant improvements in various symptoms attributed to L-Theanine. Users frequently mention enhanced mood, particularly highlighting a noticeable increase in happiness and improved cognitive clarity after consistent usage, typically around a month Read Review. Additionally, reviewers indicate a reduction in stress levels, with several noting that they feel calmer both at work and in personal relationships Read Review. As one user put it, L-Theanine helps them overcome apathy, which can often accompany stress and fatigue Read Review.
Beyond emotional benefits, several users have pointed out cardiovascular improvements, such as normalizing blood pressure and reducing risks related to heart disease. The supplement's ability to enhance focus and concentration has also been a common theme, particularly among students and professionals seeking to improve productivity without sedative effects Read Review. Overall, users advocate for L-Theanine as a valuable tool for promoting relaxation and improving mental wellness, while noting that individual results may vary Read Review.
Based on user reviews, many individuals have shared positive experiences regarding the combination of L-Theanine with other supplements for managing cardiovascular health. Users frequently highlight the synergistic effects of taking L-Theanine alongside magnesium, noting improvements in areas such as blood pressure and overall heart function. One user specifically mentioned their blood pressure and arrhythmia normalizing after combining L-Theanine with magnesium at night, which led to an excellent health check-up result Read Review.
In addition to magnesium, some reviews indicate that combining L-Theanine with caffeine can enhance cognitive performance while maintaining relaxation, suggesting a balanced approach to supplement use Read Review. Overall, users express confidence that combining L-Theanine with other supplements can yield beneficial outcomes for those looking to mitigate the risks of cardiovascular disease and improve their well-being, making it a versatile addition to a comprehensive health strategy.
Based on user reviews, L-Theanine appears to be beneficial for cardiovascular health, with many users noting improvements in stress management and overall well-being. One reviewer mentioned experiencing a significant change in calmness and familial relationships, as well as potential reductions in the risks associated with cardiovascular disease after a month of use Read Review. Another user specifically reported normalising their blood pressure and arrhythmia after incorporating L-Theanine into their routine, which they attributed to their recent health improvements Read Review.
Regarding the right dosage, one user recommended a 200 mg dosage for effective results, stating that it provides relaxation within approximately 30 minutes without inducing sleepiness Read Review. Others echoed the sentiment of dosage being important, as it appears users prefer taking the supplement at specific times, like post-meal or in the morning, to maximise its benefits on both stress and cardiovascular support Read Review. Overall, users seem to find L-Theanine an effective alternative for managing stress and promoting heart health, but precise dosing can vary between individuals.
9
Enhanced mood stability
4 people found this helpful
I’ve recommended L-Theanine for my brother as per his doctor’s advice for stress and memory issues. After a month of use, he’s noticeably happier, more judicious, and his condition has significantly improved. I believe L-Theanine is one of the best remedies. If you find this helpful, please give it a like.
7.5
Improved stress response
4 people found this helpful
If you're stressed and fatigued, this product is for you. After taking it for a month, I've noticed a significant change: I'm calmer at work, my family relationships have improved, and I've overcome apathy. L-Theanine also reduces risks for diabetes and cardiovascular disease. If this resonates with you, I suggest trying these pills for a positive change.
7.5
Effective relaxant
3 people found this helpful
This supplement is excellent, lasting four months at a reasonable price. I take it before breakfast, and it acts as a powerful relaxant without causing sleepiness. My energy levels are higher, and my depressive symptoms have lessened. The added inositol also helps in reducing bad cholesterol and supporting cardiovascular disease prevention.
6
Calms nerves effectively
6 people found this helpful
I really appreciate this supplement and have ordered it twice. Over the months, I've seen a noticeable boost in my concentration and a calmer response to stress. It doesn't induce sleepiness and has many benefits, including support for cardiovascular function and normalising blood pressure. The capsules are comfortable, and I highly recommend it to students and athletes.
7.5
Support cardiovascular health
9 people found this helpful
L-Theanine, an amino acid from green tea, promotes relaxation without drowsiness and supports the cardiovascular system. I've found it particularly effective when taken after a meal. Its effects are gradual, offering a soft sense of balance and clarity of thought without addiction or side effects. I've noticed no negative effects and consider it a noteworthy supplement that delivers on its promises.
9
Normalised blood pressure
1 people found this helpful
With my stressful job, I've taken this product with magnesium at night for a good sleep. After using L-Theanine, my arrhythmia and blood pressure have normalised, and my recent health checkup showed excellent results. I'm satisfied with the quality and will continue using this honest brand.
7.5
Supports mental performance
4 people found this helpful
L-Theanine is an amino acid that enhances focus and relaxes muscles without sedative effects. It's better than caffeine stimulants and benefits cardiovascular health by reducing risks of heart disease and blood pressure. Combining it with caffeine maximises brain function, and I highly recommend trying it.
7.5
Quick stress relief
1 people found this helpful
I've used NOW's L-Theanine for stress and anxiety effectively. The 200 mg dosage works wonders in about 30 minutes, making me feel more at ease without causing sleepiness. It's a great supplement alongside a healthy diet and exercise.
9
Inositol protects against cardiac damage
Oral supplementation of inositols effectively recovered lithium-induced cardiac dysfunctions in mice.
We investigated how inositol supplementation could counteract heart issues caused by lithium in mice. Our study involved four groups of mice to explore the varying effects of inositol. One group received lithium alone, another received lithium followed by inositol, a third group had both lithium and inositol from the start, and a control group had no treatment at all.
The results were promising. We found that inositol had a protective effect against the heart damage typically associated with lithium. Specifically, it helped improve heart function and reduced susceptibility to arrhythmias—irregular heartbeats. We also noted that inositol seemed to restore healthy levels of certain proteins crucial for heart health, helping to reduce cell enlargement and stress associated with hypertrophy.
Interestingly, the benefits of inositol were evident regardless of whether it was given alongside lithium or afterward as a treatment. These findings suggest that inositol could be a valuable addition to therapy for those facing lithium-induced cardiac issues, offering a potential pathway to better heart health.
8
ITPP improves heart function in PH
Myo-inositol trispyrophosphate prevents right ventricular failure and improves survival in monocrotaline-induced pulmonary hypertension in the rat.
We investigated the effects of myo-inositol trispyrophosphate (ITPP) on rats with pulmonary hypertension (PH), a condition that often leads to serious heart issues. To do this, we injected some rats with monocrotaline to induce PH and treated others with a placebo. For five weeks, we closely monitored their heart function using echocardiograms and other advanced techniques.
Our findings revealed that ITPP significantly reduced mortality linked to PH. While it didn't change the increasing resistance in the pulmonary vessels, ITPP importantly alleviated hypoxia within the right ventricle (RV), which is crucial for maintaining heart function. This reduction in RV hypoxia not only improved heart performance but also decreased stress on the heart’s structure.
Furthermore, we noticed that ITPP appeared to inhibit an increase in a specific protein associated with low oxygen levels, though it didn't affect the density of blood vessels in the RV. Overall, this suggests that enhancing oxygen delivery with ITPP could provide a crucial therapeutic avenue for improving heart health in patients suffering from pulmonary hypertension.
References
L'Abbate S, Nicolini G, Forini F, Lepore E, Marchetti S, et al. Oral supplementation of inositols effectively recovered lithium-induced cardiac dysfunctions in mice. Biomed Pharmacother. 2024;178:117287. doi:10.1016/j.biopha.2024.117287
Oknińska M, Paterek A, Grzanka M, Zajda K, Surzykiewicz M, et al. Myo-inositol trispyrophosphate prevents right ventricular failure and improves survival in monocrotaline-induced pulmonary hypertension in the rat. Br J Pharmacol. 2024;181:4050. doi:10.1111/bph.16482